5-Meo-DMT, aka BUFO, is popularly known as a toad’s psychedelic gift – but is now also being scientifically studied in clinical research. The compound seems ideal as a fast-acting tool for ego dissolution, with potential therapeutic use. The substance produces stunning effects that no other psychedelic appears to match and does so within a manageable time frame.

In a survey done by Johns Hopkins University of 362 adults, approximately 80 percent of respondents reported improvements in anxiety and mental calm after use. These improvements were related to more intense acute mystical effects during the 5-MeO-DMT experience, as well as increases in the rating of the personal meaning and spiritual significance of the experience. Improvements were also related to stronger beliefs that the experience contributed to enduring well-being and life satisfaction.